Reed Adamson and April Kepner were close friends. They lived together as roommates and had many things in common.
Upon arriving, she flirted with Dr. Alex Karev for some time, stating there was something special about him. She most recently had a one-night stand with Mark Sloan, which he was seeing Teddy Altman. Charles Percy was her friend and was interested in her romantically, but both were tragically killed before he had a chance to pursue a relationship.
She worked as an intern, and as a resident, at the Mercy West Medical Center until the merger with the Seattle Grace Hospital, where she was supposed to finish her residency.