Zehetner was born in El Paso, Texas, the daughter of Nancy Lynne and John Carol Zehetner. She attended elementary school in Richardson, Texas, a suburb of Dallas, before moving back to El Paso. When she was 14 she moved to Dallas where she attended McKinney High School for several years. For one year she also attended the Texas Academy of Mathematics and Science, an early college entrance program at the University of North Texas for students interested in mathematics or science.
At the age of 18 Zehetner started an acting career, something she had been interested in since she was 8, and moved to Los Angeles. She appeared in Tart (2001), American Pie 2 (2001), R.S.V.P. (2002), May (2002), and The Song of Rose (2003), as well as in other films and several TV series and commercials. Zehetner is best known for her role as Laynie Hart on the WB's show Everwood.
In Brick, which won the Special Jury Prize for Originality of Vision at the 2005 Sundance Film Festival, Zehetner plays the rich femme fatale Laura. The soundtrack CD of this film, released by Lakeshore Records on March 21, 2006, features a full unedited performance by Zehetner of "The Sun Whose Rays Are All Ablaze".
In the thriller-horror film Beneath, Zehetner appears in the leading role of Christy.
Zehetner also guest-starred in eight episodes of NBC's Heroes as Eden McCain. Zap2It.com proclaimed Zehetner one of "The Underrated of 2006" for her role.
Together with the actors and comedians Tom Arnold and Dax Shepard, Zehetner embarked in 2007 on a USO/Armed Forces Entertainment tour to the Persian Gulf region to meet with service members and sign autographs.
In 2007, Zehetner appeared with Marisa Berenson in the short movie "Jalouse: Elegante, famous, beautiful, jolie" which was produced by the French fashion magazine Jalouse to celebrate their 10th anniversary.
From late 2009 to mid 2010, she portrayed the recurring role of Dr. Reed Adamson in the popular television series Grey's Anatomy.
|2001||American Pie 2||Girl at Party|
|2003||The Burning Land||Rose|
|2005||Conversations with Other Women||Young Woman|
|2005||The Adventures of Big Handsome Guy and His Little Friend||Plain Jane|
|2008||The Brothers Bloom||Rose|
|2000||Gilmore Girls||Girl in Hallway|
|2001||Going to California||Dixie Hartnett|
|2001||An American Town||Glenn|
|2002||Point of Origin||Trish|
|2002||She Spies||Ashley Blaine|
|2006||Masters of Horror||Waiter|
|2009||Seattle Grace: On Call||Reed|
|2009-2010||Grey's Anatomy||Dr. Reed Adamson|
- "Quand Nina est saoule" from the French singer Ours (2008)