The following is a list of all current and previous main characters who have featured in Grey's Anatomy. The characters are listed in alphabetical order.
|Name||Actor/Actress||Starring Seasons||Occupation at Seattle Grace|
|Theodora "Teddy" Altman||Kim Raver||6, 7, 8||Attending Cardiothoracic Surgeon|
|Dr. Altman took over the job as Chief of Cardiothoracic Surgery at Seattle Grace in season six. She previously served in Iraq with Owen Hunt. Although a skilled surgeon, her teaching methods might appear somewhat unorthodox. Her arrival at Seattle Grace, followed by her profession of love to Owen has caused some friction between Owen and his girlfriend, Cristina Yang. Teddy marries a patient at the hospital named Henry to get him insurance, but she eventually falls in love with him. Over time, Teddy forms a friendship with Cristina, but her friendship with Owen ends when she feels he put the hospital before her. She and Owen eventually make up in the season finale. Owen finds out she was offered a job at the Army Medical Command, but turned it down because she wanted to be there for Owen, if he and Cristina were to separate. He ultimately fires her, and tells her that he'll be okay.|
|Jackson Avery||Jesse Williams||6, 7, 8, 9||Surgical Resident|
|First introduced as a surgical resident from Mercy West Hospital, he is also called "pretty boy," especially by Cristina Yang. He is a grandson of the famous surgeon, Dr. Harper Avery, and is focusing on plastics. He develops a crush on Cristina, and while inebriated he kisses her at a party, but Cristina breaks the kiss. In the sixth season finale, he is told by Dr. Shepherd that there is a lockdown in the hospital and is later left by Dr. Hunt and Dr. Altman in the OR with two nurses and one anaesthesiologist. He is the one who decides that Yang should operate on Shepherd in order to save him. When Mr. Clark (the shooter) takes the OR hostage, he disconnects Shepherd in order to make everyone believe that he is dead until Mr. Clark leaves the room. It is also revealed later in season seven that Avery suffers from traumatic nightmares. Avery also has a complicated relationship with Lexie Grey, which is a recurring plot point on the show.|
|Miranda Bailey||Chandra Wilson||1, 2, 3, 4, 5, 6, 7, 8, 9||Attending General Surgeon|
An attending general surgeon at Seattle Grace Hospital, Miranda Bailey initially gave a cold, domineering impression, earning her the nickname "The Nazi". However, her attitude has since softened, and she has developed a maternal role towards the residents in the hospital. She has undergone a divorce which led her to turn down a fellowship in paediatric surgery. She is dating an anaesthesiologist.
|Preston Burke||Isaiah Washington||1, 2, 3||Attending Cardiothoracic Surgeon|
|Preston Burke was the former Chief of Cardiothoracic Surgery. He began a romantic relationship with Cristina Yang, which came under strain when Burke was shot and his right hand's nerve supply was disrupted. With his career threatened he had Yang perform some of his surgeries, a situation which resolved when Derek Shepherd repaired Burke's nerve supply. Burke and Yang continued their relationship which ultimately ended on their wedding day, when he left her at the altar. Burke graduated at the top of his class from the Johns Hopkins University School of Medicine. In season four, Burke was mentioned to get the Harper Avery Award.|
|Alexandra "Lexie" Grey||Chyler Leigh||3, 4, 5, 6, 7, 8||Surgical Resident|
|Resident and half sister of Meredith Grey, Lexie, was in relationships with Mark, Alex and Jackson. Known for her photographic memory, she has earned the nickname Lexiepedia. Initially she had a distant, contentious relationship with Meredith, but they have since grown closer. She is often called "Little Grey" by other doctors and staff. In the season eight finale, she died from the consequences of a plane crash that took place at the end of the penultimate episode.|
|Meredith Grey||Ellen Pompeo||1, 2, 3, 4, 5, 6, 7, 8, 9||Surgical Resident|
|Resident Meredith Grey is the central protagonist of the show, and narrator of the majority of episodes. She began the series as an intern and has since progressed along her career path. Her character is defined by her romantic relationships as well as the lingering effects of her mother's affair with Richard Webber has had on her life. She is best friends with Cristina Yang and following a long romance, she has married neurosurgeon Derek Shepherd, and they adopted a baby named Zola.|
|Erica Hahn||Brooke Smith||2, 3, 4, 5||Attending Cardiothoracic Surgeon|
|Following Preston Burke's departure, Erica Hahn took his position as Chief of Cardiothoracic Surgery at Seattle Grace. Her brusque, somewhat harsh personality was tempered by Callie Torres, with whom she began a relationship. Her time at Seattle Grace ended abruptly, however, when she became discontent with Izzie Stevens, and the lack of disciplinary action following the Denny Duquette incident. Dr. Hahn attended the Johns Hopkins University School of Medicine, where she was in the same class as Dr. Burke.|
|Owen Hunt||Kevin McKidd||5, 6, 7, 8, 9||Chief of Surgery|
|Owen Hunt, Chief of Trauma Surgery, is the husband of Cristina Yang. Suffering from Post-Traumatic Stress Disorder, he has struggled with the horrors he experienced whilst serving with the army in Iraq. He invited former colleague Teddy Altman to work alongside him at Seattle Grace, a decision which caused some friction between himself and Cristina. In the season seven premiere he marries Cristina. Later, he is also offered the position by Richard Webber to choose the next chief resident at Seattle Grace. He was later promoted to Chief of Surgery after Webber resigned.|
|Alex Karev||Justin Chambers||1, 2, 3, 4, 5, 6, 7, 8, 9||Surgical Resident|
|Hard-headed and often discourteous Resident, Alex Karev has had a series of unfortunate relationships throughout his life beginning with his mother. At an early age he had to become her defender from an abusive father and later her caretaker. While working as a doctor he was involved with a patient, Ava, but her mental instability strained their relationship and Alex once again adopted a caretaker role before Ava's admission to a psychiatric hospital. He subsequently embarked on a relationship with Izzie Stevens, and they got married, but Izzie asked for a divorce following her dismissal from Seattle Grace.|
|April Kepner||Sarah Drew||6, 7, 8, 9||Chief Surgical Resident|
A surgical resident from Mercy West Hospital, she was fired in episode 6.06 by Chief Webber, but later rehired by Dr. Shepherd in episode 6.13 due to his believing her dismissal was unfair. Later it is revealed that she has a crush on Dr. Shepherd in episode 6.19. In the season six finale, she informs him that her best friend Dr. Reed Adamson has been shot and killed. She later runs into Mr. Clark (the shooter) when Shepherd was shot. Clark lets her go when she emotionally tells him everything about her life. In the third episode of season seven, April reveals that she is a virgin. In the season seven finale, April becomes Chief Resident.
|Addison Montgomery||Kate Walsh||1, 2, 3||Attending Neonatal Surgeon/Obstetrician-Gynaecologist|
|Former Chief of OB/GYN and Neonatal Surgery, and the ex-wife of Derek Shepherd, Addison transferred to Seattle Grace, seeking reconciliation with Derek. After achieving a degree of understanding with Derek and realising that he was in love with Meredith Grey, Addison left Seattle Grace. The character is now the protagonist of ABC series Private Practice and continues to make guest appearances on Grey's Anatomy.|
|George O'Malley||T.R. Knight||1, 2, 3, 4, 5||Surgical Resident|
|George O'Malley had a less aggressive personality compared with his fellow residents. He once had an infatuation with Meredith Grey which ended when they slept together, and halfway through Meredith began to cry, humiliating George. He also had a strong friendship with Izzie Stevens and later Lexie Grey. He was once married to Callie Torres, but their marriage came to an end when George slept with Izzie. George and Izzie tried a relationship but decided to remain as friends when they realised their relationship lacked chemistry. Inspired by Dr. Hunt's experiences, George decided to leave Seattle Grace and enlist in the Army. Tragically, on his way to tell his mother about joining the Army, George died from injuries sustained from rescuing a girl from being hit by a bus, sacrificing himself instead.|
|Arizona Robbins||Jessica Capshaw||5, 6, 7, 8, 9||Attending Paediatric Surgeon|
|Arizona Robbins, paediatric surgery attending, has a cheery disposition but gets upset when challenging authority. She has embarked on a relationship with Callie Torres. She comes from a military family and graduated from the Johns Hopkins University School of Medicine. She has been revealed to harbour great emotional intelligence; her insight and advice has been used to defuse several situations, such as Callie's dispute with her father. In season seven, she wins a prestigious award, and she and Callie plan to move to Malawi, Africa and work there. However, she breaks up with Callie and leaves her at the airport. They reconcile soon after, and ultimately get married.|
|Derek Shepherd||Patrick Dempsey||1, 2, 3, 4, 5, 6, 7, 8, 9||Attending Neurosurgeon|
|As Chief of Neurosurgery, Derek Shepherd earned the nickname "McDreamy" by the female staff of Seattle Grace. The lead male character, he is known for his complicated love-life. Initially he moved to Seattle from New York to get away from his adulterous ex-wife Addison Montgomery whom he discovered was having an affair with his best friend, Mark Sloan. He subsequently began a long romance with Meredith Grey which resulted in their marriage. Recently he had a somewhat antagonistic relationship with Richard Webber whom he believed wasn't governing the hospital appropriately. He took over as the Chief of Surgery after going to the hospital board about Chief Webber's drinking problem, but resigned after nearly dying from being shot because he thought being Chief wasn't his place.|
|Mark Sloan||Eric Dane||2, 3, 4, 5, 6, 7, 8, 9||Attending Plastic Surgeon|
|Mark Sloan, Chief of Plastic Surgery, has a playboy personality that nearly jeopardised his friendship with Derek by having an affair with his wife, Addison Montgomery. He knew both Derek and Addison Shepherd from when all three lived in New York. Derek and Mark managed to resolve their issues and reaffirm their friendship. He has been given the nickname "McSteamy" by Meredith and her friends. Sloan had a relationship with Lexie Grey which ended due to strain when Mark's 18 year old daughter from a one-night-stand appeared at the hospital and subsequently moved in with them. The girl's mother had named her Sloan and never told Mark about her. She arrived in Seattle unannounced, and Mark found out she was pregnant. Mark wanted to keep the baby but Sloan decided to give it up for adoption. After that, Mark and Lexie retake their relationship, but it ended when Mark got Callie Torres pregnant, and Lexie started dating Jackson Avery.|
|Isobel "Izzie" Stevens||Katherine Heigl||1, 2, 3, 4, 5, 6||Surgical Resident|
|Growing up in a trailer park and putting her newborn daughter up for adoption at age 16, Izzie managed to progress along medical school by paying her bills through modelling. She put her career as doctor on the line in a risky bid to get her lover Denny Duquette a new heart by cutting his LVAD wires. Denny subsequently died but Izzie managed to keep her job. Izzie began a relationship with Alex Karev, but their relationship came under strain when she was diagnosed with metastatic melanoma. She survived the condition following treatment with Interleukin-2 but after restarting work she accidentally induced hyperkalaemia in a patient listed for renal transplant. Subsequently she lost her job, and has since disappeared from Seattle Grace. Originally, it was planned that the character would have a proper closure to her relationship with Alex in season seven, but this did not happen.|
|Callie Torres||Sara Ramirez||2, 3, 4, 5, 6, 7, 8, 9||Attending Orthopaedic Surgeon|
|Callie is an orthopaedic surgeon. She was introduced as an orthopaedic surgical resident, and then promoted to an attending. She was once married to George O'Malley, but divorced him after he developed feelings for Izzie Stevens. Later, she had a lesbian affair with Erica Hahn which was cut short by Hahn's departure from Seattle Grace. She was in a happy relationship with Arizona Robbins but they broke up because Arizona did not want to have kids. However at the end of the sixth season, after doing a surgery on a small girl while a shooter is loose in the hospital, Callie tells Arizona in a round about way that she loves her and the two end up getting back together and decide that they are going to have children. In season seven, Callie was going to move to Africa with Arizona, but Arizona breaks up with her and then leaves her at the airport in Seattle. Callie ends up sleeping with Mark Sloan again and gets pregnant. Arizona later returns for Callie and they get back together. On episode 7.18 Callie gets horribly injured in a car crash with Arizona. Addison delivers her baby at 23 weeks, which then survives. Later Dr. Bailey marries Arizona and Callie.|
|Richard Webber||James Pickens, Jr.||1, 2, 3, 4, 5, 6, 7, 8, 9||Attending General Surgeon|
|Authority figure and former Chief of Surgery at Seattle Grace, Richard has had a difficult past characterised by affairs and alcoholism. His relationship with Meredith Grey is at time volatile because he had an affair with her mother. Recently Richard has struggled with managing the finances of Seattle Grace and has merged the hospital with Mercy West Hospital. The merger has caused him much stress, strained his relationship with Derek Shepherd and ultimately contributed to the collapse of his sobriety. He stepped down as Chief of Surgery in season eight.|
|Cristina Yang||Sandra Oh||1, 2, 3, 4, 5, 6, 7, 8, 9||Surgical Resident|
|Skilled Resident Cristina Yang has an indomitable passion for cardiothoracic surgery and is almost ruthless in pursuit of her desired specialty. She is best friends with Meredith Grey, and has previously been in a relationship with Preston Burke, which ended suddenly when he left Cristina on their wedding day. Since then she has entered into a relationship with Owen Hunt, whom she married in season seven.|
Other Medical ProfessionalsEdit
|Nurse Olivia Harper||Sarah Utterback||1, 2, 3, 4, 6|
|A nurse at the hospital. She had relationships with George and Alex. Alex gave her syphilis which she then unknowingly gave to George after breaking up with Ales (which was part of a hospital-wide syphilis epidemic among the doctors and nurses). After that, Alex began a relationship with Izzie, who then found him cheating on her with Nurse Olivia. The female intern occasionally insultingly refer to her as "Syph Nurse." She was also in the club "Nurses United Against Mark Sloan" which implies she has had sexual relations with him. During the merger, she is fired and Derek offers to give her a recommendation.|
|Nurse Tyler Christian||Moe Irvin||1, 2, 3, 4, 5, 6, 7|
|Nurse Tyler is one of the members of the nursing staff at Seattle Grace. He attended the nurse strike in season two.|
|Patricia||Robin Pearson Rose||1, 2, 3, 5|
|Patricia is Richard Webber's assistant/secretary and had previously worked as a nurse.|
|Dr. Sydney Heron||Kali Rocha||2, 3, 4|
|A fifth year general surgery resident at Seattle Grace, known for her extremely perky personality. She initially appeared as Bailey's substitute when Bailey was on maternity leave and clashed with Cristina, who finds Sydney's positive attitude unbearable. She later served as Izzie's peer counsellor and revealed that her perky persona actually originated from a nervous breakdown she suffered after losing a patient of her own. She was also in the running to become Chief Resident, but lost to Callie, who later replaced Bailey. Sydney also went on one date with Dr. Shepherd, but dumped him when she decided he wasn't ready for the kind of relationship she needed.|
|Dr. Katharine Wyatt||Amy Madigan||4, 5, 6|
|A psychiatrist at the hospital, she was Dr. Meredith Grey's and Dr. Erica Hahn's therapist. As of "Sweet Surrender", Dr. Owen Hunt has begun sessions with her.|
|Dr. Steve Mostow||Mark Saul||4, 5, 6, 8|
|A surgical intern of Dr. Cristina Yang, who calls him "2" in "There's no 'I' in Team", Dr. Yang considered "giving" him to George O'Malley when he finally passed his medical exams. Later on, Steve allowed the other interns to practise on epidural anaesthesia on him, and introduce a catheter onto his male organs; because of this he couldn't move for a while and thus was not present at Sadie's operation. Dr. Yang found him immobilised and thus found out about the operation. Steve was put on probation along with the other interns. Later in the season, Steve slept with fellow intern Pierce's girlfriend Megan, and she got pregnant. It's revealed in the sixth season that Steve and Megan got married, and concluding that he was the father. During the merger Megan is fired, but Steve keeps his job, although he's later hired back by Derek Shepherd. According to his blog, he has aspirations to go into neurosurgery as a speciality.|
|Dr. Graziella Guzman||Gloria Garayua||4, 5, 6|
|A surgical intern of Dr. Izzie Stevens, who considered giving her to George O'Malley because she charts like crap, but kept her because she can put in a line. Graziella is a nervous student, who eats a lot of chocolate when nervous. In the episode "In The Midnight Hour", she was the only one who quit the interns' operation on Sadie because she felt it was wrong; nevertheless, she was put on probation with the other interns.|
|Intern Pierce||Joseph Williamson||4, 5, 6|
|A surgical intern of Dr. Alex Karev, who considered giving him to George O'Malley just because he hates how his name sounds. Pierce has confronted Dr. Karev in at least one occasion, when he met his punishment along with the other interns in the episode "In The Midnight Hour" and commented that Dr. Stevens killed a man and was forgiven; Dr. Karev responded by physically attacking him. Later on in the season, Pierce and Steve fought over Megan, Pierce's girlfriend who slept with Steve during a break-up, and now she's pregnant without knowing who is the father to her baby.|
|Dr. Ryan Spalding||Brandon Scott||5, 6|
|A surgical intern of Dr. Cristina Yang, who considered giving him to George O'Malley, first appeared in "Life During Wartime" and was subsequently named "4.2". In the episode "In The Midnight Hour" Ryan was one of the surgical interns operating on Dr. Sadie Harris. He was left on his own in an OR, while the others went to get help. He was put on probation with the other interns, after Sadie nearly died in the operation.|
|Dr. Megan Mostow||Molly Kidder||4, 5, 6|
|Resident and former intern of Dr. Meredith Grey's, who she considered giving to George O'Malley. She had a relationship with intern Pierce which ended when she had an affair with Steve that resulted in a pregnancy. During the hospital merger The Chief fired her by e-mail. Later she decided to sue the hospital, believing her dismissal was related to her pregnancy. She was later rehired by Derek Shepherd, who believed she was fired injustly and deserved a "fighting chance."|
|Intern Laura||Candice Afia||4, 5, 6|
|Former surgical intern under Dr. Alex Karev. Laura was rebuked by Izzie Stevens when she made fun of a patient with a facial deformity.|
|Dr. Raj Sen||Anjul Nigam||1, 2, 4|
|A psychiatric resident at Seattle Grace. He sometimes provides consults for the surgeons.|
|Dr. Virginia Dixon||Mary McDonnell||5|
|An exceptional cardiothoracic surgeon was Asperger Syndrome, and served as the interim Head of Cardiothoracic Surgery.|
|Dr. Swender||Kimberly Elise||5|
|A surgical oncology attending assigned to oversee Izzie Stevens' cancer treatment. She is said to be the best surgical oncologist in the state of Washington. Swender is a proponent for IL-2 use as treatment for cancer; she reasons its success when a patient, initially given only three months to live, uses the therapy and survives an additional two years. The patient, however, succumbs to complications due to the inherent nature of the IL-2. This has shown to affect Swender's otherwise authoritarian and impartial persona, and casts doubt on this treatment-protocol.|
|Dr. Margaret Campbell||Faye Dunaway||5|
|A general surgery attending and Seattle Grace's first female surgeon. With forty-years of surgical experience, she is considered a pioneer and one of the hospital's most respected surgeons; it is implied that, in that time, Richard Webber was taught by her as she recalls an incident involving a clamp dropped into an open body cavity, and has worked with Ellis Grey. More recently, Cristina Yang has been vocal about her objections and criticisms of Campbell's continued long-standing service. Due to a complication caused by a lacerated bowel during a routine cholecystectomy, Campbell shortly retires after performing her last surgery to repair the "careless mistake."|
|Dr. Sadie Harris||Melissa George||5|
|An intern and former best friend of Meredith. She reveals self-harm tendencies and later quite Seattle Grace after her medical knowledge and expertise are called into question.|
|Dr. Colin Marlowe||Roger Rees||3|
|A professor at Stanford University and brilliant cardiothoracic surgeon (noted for pioneering a procedure called the Marlowe transplant), Colin Marlowe had a three-year relationship with Cristina before she graduated and began her residency at Seattle Grace. He appeared months later as a candidate for Chief of Surgery, and ultimately withdrew as his true purpose to rekindle his relationship with Cristina failed.|
|Dr. Norman Shales||Edward Herrmann||4|
|An elderly surgical intern assigned to second year Dr. Alex Karev. Dr. Shales is a former pharmacist who because of his age is often mistaken by patients as the senior physician. He has since transferred into Psych.|
|Nurse Rose||Lauren Stamile||4, 5|
|A nurse at the hospital. She works often with Dr. Derek Shepherd. She has been the attending nurse on over 30 of Dr. Shepherd's surgeries, as Rose stated in "Forever Young" (season four, episode eight). Derek and Rose shared a kiss and were dating, much to Meredith's distress as she tried to get over him. Despite their seemingly happy relationship, Rose was soon bothered by comments made by hospital personnel about Meredith and Derek's break-up only being temporary which ended up being true when Derek and Meredith get back together for good. For example, Addison Montgomery sarcastically called Rose the "McRebound," unaware that Rose was in the room. Her prediction proved correct when in the season finale, "Freedom," Derek and Meredith make up and share a kiss. Derek abruptly leaves this kiss to break up with Rose, signalling the end of their relationship. Afterward, Rose was hostile towards Derek whenever she saw him but when she accidentally cut his hand during a surgery, she apologised and transferred to peds.|
|Dr. Finn Dandridge||Chris O'Donnell||2, 3|
|The former veterinarian of Meredith and Derek's dog, Doc. He was also the newest love interest for Meredith for some time before she broke up with him because she was still in love with Derek. His wife, Liz, died in a car accident. The interns have given him the nickname "McVet", in accordance with Derek Shepherd's nickname, "McDreamy". He dated Meredith throughout the end of the second season, and the beginning of the third season. He competed with Derek Shepherd for Meredith's heart and ultimately lost to Derek because Meredith was still in love with him. Meredith realised that he may be the "best guy," but he wasn't "her guy." After she told him this, he replied by saying, "He'll break your heart again Meredith, and when he does, I won't be here" and walked out for the last time.|
|Dr. Benjamin "Ben" Warren||Jason George||6, 7, 8|
|Anaesthesiologist from Mercy West Hospital and boyfriend of Miranda Bailey until she broke up with him after the shooting, finding herself unstable to be in a relationship after such a traumatic experience. Ben tries to stay away from Miranda after that, but they eventually start working together again. He's then asking Miranda about her new relationship with nurse Eli. Bailey wants him to stay out of her life. However she eventually ends things with Eli and reunites with Ben. As he wants Bailey to move in with him, she tells him to take it slow. He proposes to Miranda during the show's eighth season, which she accepts.|
|Dr. Reed Adamson||Nora Zehetner||6|
|Surgical resident, formerly at Mercy West Hospital. She was close friends with Dr. Charles Percy and Dr. April Kepner. She seemed to be attracted to Alex Karev, and she had a one night stand with Mark Sloan. She was shot in the head by Gary Clark in the season six finale.|
|Dr. Charles Percy||Robert Baker||6|
|Surgical resident, formerly at Mercy West Hospital. He was often referred to as "the big guy." He was in love with Dr. Reed Adamson. Percy was shot by Gary Clark in the season six finale, and despite Miranda Bailey's efforts, he died.|
|Dr. Robert Stark||Peter MacNicol||7|
|An incompetent paediatric surgery attending brought on as the interim Chief of Paediatric Surgery when Arizona Robbins gave her notice to oversee a paediatric surgery program in Malawi, Africa. Under contract for a year, Stark continues to serve as the department chief when Robbins returns. Described as a lazy doctor and a complacent and self-satisfied attending, Stark represents the antithesis of attending surgeons commonly employed at Seattle Grace/Mercy West Hospital. Stark has an antagonistic disposition with most of the hospital staff, especially Alex Karev. April Kepner is the only exception to his behaviour, whom he later attempted to date with little success.|
|Dr. Lucy Fields||Rachael Taylor||7|
|An OB/GYN attending and maternal-foetal medicine fellow at Seattle Grace Mercy West. Self-proclaimed as being "damn good at her job," Fields attended Harvard Medical School and completed her OB/GYN residency at Duke University Medical Center. Fields is also Callie Torres's obstetrician and shows that she is equal parts tough, ironic and empathetic, especially when dealing with Torres and her support team; Mark Sloan and Arizona Robbins. It also seems that she has a slight crush on Alex Karev, and in episode 18 they start to form a relationship. Also, Dr. Addison Montgomery comes back and is told that she is not able to deal with traumatic pregnancy cases. (Callie being pregnant in a car accident). Alex Karev breaks off the relationship he had with her in the season seven finale.|
Meredith and Lexie Grey's Family:Edit
Ellis Grey (Kate Burton, Sarah Paulson (1982 flashback): Meredith's mother. She was a highly respected surgeon who trained at Seattle Grace with Dr. Webber. During their residency, she and Webber had an affair; she left her husband Thatcher for him, but he could not bring himself to leave his wife. After her residency, she left Seattle to take a position at Massachusetts General. She also worked at the Mayo Clinic. She won the Harper Avery Award twice, and she invented the laprascopic Grey method. She developed early onset Alzheimer's shortly before Meredith started medical school, and at the start of the show she had been placed in Roseridge Home for Extended Care, a nursing home. She died in the middle of season three of cardiac arrest. In "Drowning on Dry Land" she appears to her daughter encouraging her to back and live her life. She also appeared in an alternative reality episode from season eight, called "If/then".
Thatcher Grey (Jeff Perry): Father of Meredith and Lexie Grey. He was married to Ellis Grey, Meredith's mother, for about seven years. They divorced after she had an affair with Richard Webber. Thatcher blames Ellis somewhat for his estrangement from Meredith, saying Ellis was "cold" and wouldn't let him get to know his daughter. After the disintegration of his first family, Thatcher remained in Seattle and married his second wife, Susan. They had two daughters, Lexie and Molly. After Meredith moved to Seattle for her residency, Susan encouraged Thatcher and Meredith to develop a relationship. However, Susan's sudden death devastated Thatcher, and he blamed her death on Meredith. He became an alcoholic, and Lexie had to give up a residency at Massachusetts General Hospital to move to Seattle to care for her father. He eventually went to rehab and apologised to his daughters; however, his alcoholism had destroyed his liver, and Meredith had to give him a portion of hers to save his life.
Susan Grey (Mare Winningham): The second wife of Thatcher Grey, and mother of Lexie Grey and Molly Grey Thompson. Susan was always aware of Thatcher's first wife and daughter, but she didn't meet Meredith until Molly was a patient at Seattle Grace. She reached out to Meredith and encouraged her to develop a relationship with Thatcher. At first, Meredith resisted Susan's attempts to mother her, but eventually she came to think of Susan as a surrogate mother. Susan died suddenly, following a rare complication from a routine procedure to treat her acid reflux and hiccups. Thatcher was devastated by her death and became an alcoholic.
Molly Grey Thompson (Mandy Siegfried): Daughter of Thatcher and Susan Grey, and Lexie's younger sister and Meredith's half sister. She proposed to her husband, Eric, before he was shipped out by the military to be stationed in Iraq. Originally a patient at Mercy West, Molly transferred to Seattle Grace when she was 32 weeks pregnant and Addison operated to repair a congenital diaphragmatic hernia on Molly's baby. She later gave birth to a daughter, whom she named Laura.
Laura Thompson: Daughter of Molly Grey and Eric Thompson. Was born premature and was kept at Seattle Grace Hospital several weeks after her birth, prompting her grandfather to hang around.
Zola Shepherd: Adoptive daughter of Meredith and Derek. She was brought over with the children from Africa, under the direction of Karev in season seven. She suffered from a spinal disease, but was treated by directed with a shunt.
Derek Shepherd's Family:Edit
Carolyn Maloney Shepherd (Tyne Daly): Derek's mother. Cared for Derek and his sisters after her husband was murdered.
Addison Montgomery: Derek's ex-wife who cheated on him with Mark. She comes to Seattle at Richard's request and the two attempt to reconcile. She ultimately moves to Los Angeles.
Kathleen Shepherd: One of Derek's sisters. Only mentioned on the show.
Nancy Shepherd (Embeth Davidtz): One of Derek's sisters. She slept with Mark as stated in the episode "Let The Angels Commit" when she told him "Come on Derek. Everyone sleeps with Mark."
Amelia Shepherd (Caterina Scorsone): Derek's sister and the youngest Shepherd child. She and Derek witnessed their father being murdered. She became addicted to prescription medication before crashing Derek's car while under the influence. Amelia works with Addison in Los Angeles and Amelia also slept with Mark as did Nancy and Addison before her.
Zola Shepherd: Adoptive daughter of Meredith and Derek.
Cristina Yang's Family:Edit
Helen Yang Rubenstein (Tsai Chin): Cristina's mother. Helen and Cristina's father divorced, and she remarried Dr. Saul Rubenstein, an oral surgeon, when Cristina was three. She thinks Cristina should focus more on getting married and less on her career.
Izzie Stevens' Family:Edit
Robbie Stevens (Sharon Lawrence): Izzie's mother. She works as a waitress.
Hannah Klein (Liv Hutchings): Izzie's biological daughter, born when Izzie was sixteen years old. In the third season, Hannah is admitted to Seattle Grace Hospital with leukaemia, and Izzie donates bone marrow to her. However, Hannah refuses to see her.
Richard Webber's Family:Edit
Adele Webber (Loretta Devine): Dr. Webber's wife. She was frequently frustrated by his devotion to the hospital, and she eventually left him. She became pregnant with his child but had a miscarriage. They have since reconciled. She was recently diagnosed with Alzheimer's disease.
Camille Travis (Tessa Thompson/Camille Winbush): Daughter of Adele's sister Ariene and Dr. Webber and Adele's niece. She was diagnosed with ovarian cancer when she was fourteen, and the cancer returned when she was a senior in high school. Dr. Bailey ordered the interns to plan a prom in the hospital for her.
Arlene Travis (Shelley Robertson): Adele's sister and Camille's mother.
George O'Malley's Family:Edit
Harold O'Malley (George Dzundza): Father of George O'Malley. He was a truck driver was a passion for vintage cars. He was married for forty years to his wife, Louise, and they had three sons: Jerry, Ronny and George. He was very proud of all of his sons, but he often had trouble relating to George. He was admitted to Seattle Grace with oesophageal cancer that had spread to his stomach, as well as a leaking aortic valve. He underwent surgery to replace his aortic valve, which was successful, and later had a second surgery to determine the extent of the cancer. Prior to the second surgery, he had asked Dr. Webber and Dr. Bailey to remove the tumour regardless of the risk in order to give him a chance to fight the cancer. The surgery proved too much for his body, and after several days, he went into multi-system organ failure, which prompted the family to take him off life support.
Louse O'Malley (Debra Monk): George's mother. She works as a teacher. George seems to find her a little overbearing, and is often embarrassed by her good-natures gestures, such as setting out breakfast for the interns during rounds and offering to iron his scrubs. She is a devout Catholic, and she is very upset when George and Callie get divorced.
Jerry O'Malley (Greg Pitts): George's brother. He works at a dry cleaners.
Ronny O'Malley (Tim Griffin): George's brother. He works at the post office.
Alex Karev's Family:Edit
Aaron Karev (Jake McLaughlin): Alex's younger brother. He works as a mover. He is very nice and polite, which is why Cristina named him "Angel Spawn" while she calls Alex "Evil Spawn". He comes to Seattle Grace with a hernia, which Dr. Bailey successfully repairs. He's very chatty and tells the doctors about his and Alex's troubled childhood. He is later diagnosed with schizophrenia after he suffers a psychotic break and tries to kill his younger sister, Amber. As a result, he had been committed to a psychiatric ward.
Amber Karev: Alex's younger sister. She is a high school student. Aaron is trying to convince her to go to college, but she doesn't see the point.
Miranda Bailey's Family:Edit
Tucker Jones: Miranda's ex-husband who divorced her because she spent more time working than at home with him and Tuck. Tucker was operated on by Derek when he got into a car accident on his way to the hospital for their son's birth.
William George "Tuck" Bailey Jones: Miranda's son with her ex-husband Tucker.
Mark Sloan's Family:Edit
Sloane Riley (Leven Rambin): Mark's biological daughter. As an 18 year old, she gives birth to Mark's grandson and puts him up for adoption.
Sofia Torres: Mark's daughter with Callie Torres. She was born prematurely as Sofia Robbin Sloan Torres on March 31, 2011. She was conceived after Mark and Callie began several trysts when the latter was left in the airport by Arizona Robbins.
Grandson: Mark's grandson through Sloan who was given up for adoption.
Teddy Altman's Family:Edit
Henry Burton (Scott Foley): Husband of Dr. Teddy Altman. She meets him and marries him in season seven so that he can use her health insurance to cover the ongoing costs of his treatment for Von Hippel-Lindau disease. He dies in season eight while undergoing surgery.
Callie Torres's Family:Edit
Carlos Torres (Hector Elizondo): Father to Callie Torres. He originally was against his daughter's homosexuality and relationship with Dr. Arizona Robbins.
Lucia Torres (Gina Gallego): Mother to Dr. Callie Torres. She has problems with accepting her daughter's sexuality and refused to attend her wedding to Arizona Robbins.
Aria Torres: Callie's sister. Only mentioned on the show.
Uncle Berto: Callie's uncle, whom she assumed might be gay aswell, stating that "he hasn't been single for sixty years for no reason".
Sofia Torres: Daughter. She was born prematurely as Sofia Robbin Sloan Torres on March 31, 2011. She was conceived after Mark and Callie began several trysts when the latter was left in the airport by Arizona Robbins.
Arizona Robbins: Wife/Civil Partner. Paediatric surgery attending, comes from a military family and graduated from the Johns Hopkins University School of Medicine.
Arizona Robbins' Family:Edit
Colonel Daniel Robbins (Denis Arndt): United States Marine Corps and Arizona's father.
Barbara Robbins (Judith Ivey): Arizona's mother.
Timothy Robbins: Arizona's brother. He died in the Iraq war.
Sofia Torres: Daughter/Stepdaughter. She was born prematurely as Sofia Robbin Sloan Torres on March 31, 2011. She was conceived after Mark and Callie began several trysts when the latter was left in the airport by Arizona. She's not legally biologically related to Arizona, but Callie and Arizona agreed on getting some sort of paper that would give Arizona some rights as Sofia's parent.
Callie Torres: Wife/Civil Partner. Head of orthopaedic surgery at Seattle Grace Mercy West Hospital.
Jackson Avery's Family:Edit
Dr. Harper Avery: Harper is the grandfather of Jackson and a world renowned surgeon.
Dr. Catherine Avery: Avery's mother and brilliant urological surgeon, appeared at Seattle Grace Mercy West to perform the "first" penis transplant in the US. She also proctored the boards in San Francisco, when she also had a one night tryst with Dr. Webber.
Other Minor CharactersEdit
- Joe the Bartender (Steven W. Bailey): The owner of the Emerald City Bar, located across from the hospital, where the doctors often go for a drink. Joe collapsed due to an aneurysm in "Raindrops Keep Falling on my Head", and Derek and Burke performed a stand-still surgery to repair it. Joe and his boyfriend Walter attended the Thanksgiving Izzie hosted at Meredith's house, and they went on a camping trip with Dr. Shepherd, Burke, Webber, Karev and O'Malley. During this trip, Joe revealed during a discussion with the Chief that although he and Walter had been "on-and-off" for about ten years, they were now committed and considering the possibility of children. They are one of two couples being considered as adoptive parents for a young mother's twins.
- Walter (Brian Reid/Jack Yang): Joe's boyfriend. Walter has been played by Jack Yang in all of his appearances except in the episode "Let It Be", where he is played by Brian Reid.
- Bonnie Crasnoff (Monica Keena): A patient admitted to Seattle Grace Hospital after being in a train crash. She and another passenger, Tom, were connected by a large metal pole passing through their bodies. Since moving the pole would kill them, the doctors decided to move one of the patients off the pole, then operate around the pole to repair the damage in the other patient. Since her injuries were more severe, they decided to move her, and she died almost immediately. Bonnie reappeared in season three as part of Meredith's dream after drowning.
- Dennison "Denny" Duquette, Jr. (Jeffrey Dean Morgan): A patient waiting for a heart transplant. He developed a close relationship with Izzie Stevens, and eventually proposed to her. Izzie risked her career to save him by cutting his LVAD wire, insuring that he would become so ill that he would get a new heart. He died shortly after the transplant from a blood clot. He reappeared in season three, as part of Meredith's dream after drowning, and again in season five. Izzie began to see Denny everywhere, which was eventually revealed to be a symptom of her brain tumour. He first appeared in the season two episode, "Begin the Begin", and made his last appearance in the season five episode "Here's to Future Days".
- Dylan Young (Kyle Chandler): The commanding officer of the Seattle PD bomb squad that responded to the bomb scare. He helped to keep Meredith calm as she held the bomb located inside a patient's body. She removed the bomb safely from the patient, but it exploded while Dylan carried it out of the OR. He reappeared in season three as part of Meredith's dream after drowning.
- Amanda (Shannon Lucio): A young woman saved from being hit by a bus by George, who was subsequently dragged several yards by the bus. Amanda was extremely concerned about him, and she stayed with him in the ICU and referred to him as "her prince." She attended George's funeral and cried harder than his own mother. Amanda kept a daily vigil outside the hospital until Izzie confronted her, pointing out that she was still alive thanks to George, and that she should honour him by living her life.
- Rebecca Pope or Ava (Elizabeth Reaser): A patient suffering from amnesia after being badly injured in the ferry crash. She was discovered by Dr. Alex Karev, and they developed a very close relationship. While at Seattle Grace, she delivered a baby girl and underwent facial reconstruction surgery, performed by Dr. Mark Sloan. She eventually regained her memory and went home with her husband, Jeff, although before leaving she pleaded with Alex to "give her a reason to stay." She returned six weeks later claiming to be pregnant with his child. Although initially upset, Alex eventually became excited about having a baby with her; however, it was revealed that she was suffering from a hysterical pregnancy. When she attempted suicide, Izzie intervened and had her admitted to the psychiatric ward. Elizabeth Reaser was nominated for the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series at the 59th Ceremony, for her role on the show.
- Gary Clark (Michael O'Neill): Husband of a patient at Seattle Grace. His wife was treated by Dr. Lexie Grey and Dr. Webber. After surgery his wife went into a coma, and since she had earlier signed a DNR, she was taken off of life support. Clark filed a lawsuit against Dr. Shepherd for wrongful death, but lost. In the season six finale, he returned to the hospital intending to kill Dr. Shepherd, Dr. Lexie Grey and Dr. Webber. He ended up shooting several other people, including Dr. Shepherd, Dr. Owen Hunt, Reed Adamson, Charles Percy and Alex Karev. After a tense standoff with Dr. Webber, he used his last bullet to commit suicide instead of killing Dr. Webber.
- Mary Portman (Mandy Moore): She was Miranda Bailey's patient during the Seattle Grace shooting. She is the wife of Bill Portman. She helped Miranda attempt to save the life of Charles Percy and despite their efforts he died. She returned to the hospital six months later to have the colostomy reversal she was supposed to have the day of the shooting. The surgery was successful, but sadly, Mary never woke up. She was taken off of life support one month later and died.
- Bill Portman (Ryan Devlin): Husband of Mary Portman.